‘One and done’ HTA success
The phrase ‘one and done’ has become routine vocabulary within the Tolley team over recent years and has become synonymous with Health Technology Assessment (HTA) success. In a UK HTA context, we use the phrase to refer to a National Institute for Health and Care Excellence (NICE) submission that achieves positive guidance and successful reimbursement […]
Challenges and opportunities in rare disease modelling
In a rare disease context, the uncertainties around evidence can be particularly high. Small patient populations can constrain the feasibility of large-scale recruitment into clinical trials, registries and other sources of real-world evidence are often limited, and established practices in terms of clinical management can be poorly evidenced or highly heterogeneous. The challenges that these […]
Publication of the SLR and NMA for a non-statin, lipid-lowering therapy for patients with hypercholesterolaemia following successful reimbursement through NICE.
Systematic literature reviews (SLRs) play an essential role in health technology assessment (HTA), providing the basis for the evidence presented in a technology appraisal submission. Methodologically flawed SLRs and/or non-transparent reporting of SLRs can raise suspicion and influence an appraiser’s confidence in the evidence to support the clinical and cost-effectiveness case. Our client required an […]